In the realm of molecular biology and gene therapy, lentiviral vectors have emerged as transformative tools for delivering genetic material into diverse cell types, including non-dividing cells. At Creative Biogene, our Custom Lentivirus Production Service leverages the QVirus™ platform, ensuring a high safety profile and remarkable gene delivery efficiency across various model organisms. What Makes Lentiviral Vectors Exceptional?Lentiviral vectors are adept at transducing a wide array of effector molecules—ranging from cDNA to RNAi constructs. This capability extends their utility to stable gene expression in mammalian cells and enables groundbreaking applications in gene therapy. Key advantages of utilizing lentiviral vectors include: Capacity for Long Sequences: Accommodating extensive genomic sequences for diverse applications.Non-Immunogenic: Designed to minimize immune responses, enhancing safety and effectiveness.Transduction of Non-Dividing Cells: Unique ability to integrate into the genomes of non-dividing cells, opening doors for innovative therapies.Stable Expression: Lentiviral integration into cellular DNA allows for persistent protein expression.Comprehensive Production ServicesOur meticulous lentiviral production process includes: Genetic material synthesis (cDNA, miRNA, shRNA, etc.)Lentiviral plasmid vector constructionPackaging of lentivirusPurification processes to ensure high titerTitration services to determine efficacyFlexible Titer Options for Diverse ApplicationsWe offer various titer levels: Regular Titer: >10⁷ TU/ml for standard cell cultures.High Titer: >10⁸ TU/ml for challenging cell types, like suspension cells.Ultra-high Titer: >10⁹ TU/ml suitable for primary cells and stem cells, as well as in vivo applications.Applications of Our ServiceThe implications of our custom lentivirus production are vast: Gene transfer and genome editing for expression or silencing of target genes.Generation of stable cell lines.CRISPR-based knock-in and knock-out cell line creation.Engineering CAR T-cells for personalized cancer therapy.Production of transgenic animal models.Advancements in gene therapy research.Our Commitment to ExcellenceWith over a decade of experience, our team has successfully constructed and purified thousands of lentiviruses, catering to clients worldwide. The QVirus™ platform guarantees optimized systems, reduced risks, and consistent results. If you have specific requirements or wish to learn more, feel free to connect with us.